Sphingosine-1-Phosphate: Biomarker, Contributor, or Target for Asthma?
نویسندگان
چکیده
منابع مشابه
Vascular endothelium as a contributor of plasma sphingosine 1-phosphate.
Sphingosine 1-phosphate (S1P), an abundant lipid mediator in plasma, regulates vascular and immune cells by activating S1P receptors. In this report, we investigated the mechanisms by which high plasma S1P levels are maintained in mice. We found that plasma S1P turns over rapidly with a half-life of approximately 15 minutes, suggesting the existence of a high-capacity biosynthetic source(s). Tr...
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Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade. Sphingolipid metabolites, such as ceramide and S1P (sphingosine 1-phosphate), have been demonstrated to have roles as potent bioactive mes...
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Sphingosine 1-phosphate (S1P) is involved in a wide range of cellular processes, which include proliferation, apoptosis, lymphocyte egress, endothelial barrier function, angiogenesis, and inflammation. S1P is produced by two isoenzymes, namely, sphingosine kinase 1 and 2 (SphK1 and 2) and once produced, S1P can act both in an autocrine and paracrine manner. S1P can be dephosphorylated back to s...
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Results All three groups of patients had significantly (P < 0.001) lower serum S1P concentrations than controls (median 457.9 μg/L; interquartile range, IQR 379.8-562.3 μg/L). The lowest S1P concentrations was found in the septic shock group (149.1 μg/L; IQR, 105.1-163.2 μg/L) compared to patients with severe sepsis (234.7 μg/L; IQR, 185.4-342.6 μg/L) and sepsis (246.7 μg/L; IQR, 201.7306.0 μg/...
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Pulmonary hypertension is characterized by extensive vascular remodelling, leading to increased pulmonary vascular resistance and eventual death due to right heart failure. The pathogenesis of pulmonary hypertension involves vascular endothelial dysfunction and disordered vascular smooth muscle cell (VSMC) proliferation and migration, but the exact processes remain unknown. Sphingosine 1-phosph...
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ژورنال
عنوان ژورنال: Allergy, Asthma & Immunology Research
سال: 2019
ISSN: 2092-7355,2092-7363
DOI: 10.4168/aair.2019.11.3.299